Vinyl Chloride Carcinogen

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Vinyl chloride carcinogen.

It is made softer and more flexible by the addition of phthalates and can contain traces of chemicals like bisphenol a bpa. Vinyl chloride is a mutagen having clastogenic effects which affect lymphocyte chromosomal structure. Vinyl chloride is used to make polyvinyl chloride pvc. Carex carcinogen exposure is an inter national information system on occupational exposure to known and suspected carcinogens.

Department of health and human services has determined that vinyl chloride is a known carcinogen. World health organization 2012. It can be formed when other substances such as trichloroethane trichloroethylene and tetrachloroethylene are broken down. Vinyl chloride iarc monographs on the evaluation of carcinogenic risks to humans volume 100f.

Polyvinyl chloride pvc is a solid plastic material made from vinyl chloride. Where risks occur the main route of occupational exposure to vinyl chloride is by inhalation which occurs primarily in vinyl chloride pvc plants and in pvc processing plants including packaging storage and handling of. Vinyl chloride is classified as group 1 carcinogen by the iarc meaning it is seen as a definite cause of cancer in humans. Pvc is used to make pipes polyvinyl flooring and siding hoses cable coatings medical devices and plumbing and automotive parts.

It is a manufactured substance that does not occur naturally. The international agency for research on cancer has determined that vinyl chloride is carcinogenic to people and epa has determined that vinyl chloride is a human carcinogen. It burns easily and it is not stable at high temperatures. Vinyl chloride vc is a human carcinogen known to undergo metabolism by cytochrome p450 2e1 cyp2e1 to reactive intermediates that can cause oncogene and tumor suppressor gene mutations and that are further metabolized by acetaldehyde dehydrogenase aldh2 and glutathione s transferases gsts to non mutagenic end products.

It has a mild sweet odor. Vinyl chloride is used primarily 95 in the manufacture of polyvinyl chloride pvc which comprises about 12 of the total use of plastic. Epa s integrated risk information system iris is a human health assessment program that evaluates information on health effects that may result from exposure to environmental contaminants.

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